James G Martin Selected Research

Respiratory Hypersensitivity

11/2020	Cellular Source of Cysteinyl Leukotrienes Following Chlorine Exposure.
1/2019	HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis.
1/2019	Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells.
1/2018	March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.
10/2017	Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse.
1/2017	The TLR4-TRIF pathway can protect against the development of experimental allergic asthma.
1/2017	Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice.
1/2016	CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma.
11/2015	Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility.
4/2015	Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse.

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James G Martin Research Topics

Disease

59	Asthma (Bronchial Asthma) 10/2022 - 05/2002
44	Inflammation (Inflammations) 10/2022 - 05/2002
28	Respiratory Hypersensitivity 11/2020 - 01/2003
20	Airway Remodeling 01/2017 - 12/2002
14	Eosinophilia 01/2019 - 05/2002
8	Pneumonia (Pneumonitis) 01/2019 - 08/2010
7	Hyperplasia 07/2012 - 09/2003
5	Infections 01/2022 - 01/2012
4	Fibrosis (Cirrhosis) 01/2021 - 08/2008
4	Virus Diseases (Viral Diseases) 01/2019 - 01/2006
4	Hypersensitivity (Allergy) 01/2018 - 06/2007
4	Cystic Fibrosis (Mucoviscidosis) 04/2013 - 11/2005
3	Lung Injury 10/2019 - 03/2011
2	Emphysema 01/2021 - 01/2006
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019 - 06/2015
2	Airway Obstruction (Choking) 11/2018 - 02/2014
2	Occupational Asthma 05/2017 - 09/2003
2	Respiratory Sounds (Crackle) 04/2013 - 07/2010
1	Human Influenza (Influenza) 01/2022
1	COVID-19 11/2021
1	Hyperoxia 01/2021

Drug/Important Bio-Agent (IBA)

25	AllergensIBA 01/2021 - 05/2002
21	CytokinesIBA 01/2019 - 01/2007
11	OvalbuminIBA 01/2021 - 01/2003
10	ChlorineIBA 01/2021 - 09/2003
9	Methacholine Chloride (Methacholine)FDA Link 10/2017 - 08/2008
9	Proteins (Proteins, Gene)FDA Link 06/2015 - 05/2003
8	Interleukin-5 (Interleukin 5)IBA 01/2019 - 10/2002
7	Irritants (Vesicants)IBA 01/2021 - 07/2010
7	Interleukin-13IBA 01/2018 - 05/2003
6	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2021 - 04/2007
6	Interleukin-4 (Interleukin 4)IBA 01/2018 - 10/2002
6	AntigensIBA 11/2013 - 03/2005
5	Interleukin-8 (Interleukin 8)IBA 04/2013 - 09/2005
5	Messenger RNA (mRNA)IBA 08/2012 - 10/2002
4	AntioxidantsIBA 10/2019 - 10/2010
4	Biomarkers (Surrogate Marker)IBA 05/2017 - 11/2006
4	ChemokinesIBA 09/2015 - 01/2007
4	Interleukin-17 (Interleukin 17)IBA 09/2015 - 04/2010
3	Fluticasone (Cutivate)FDA LinkGeneric 10/2022 - 11/2012
3	SteroidsIBA 10/2022 - 08/2010
3	AntibodiesIBA 01/2022 - 05/2003
3	InterleukinsIBA 10/2020 - 01/2003
3	LeukotrienesIBA 10/2017 - 01/2003
3	1,3-dimethylthioureaIBA 01/2016 - 10/2010
3	LigandsIBA 04/2012 - 06/2007
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 01/2006
2	Prednisone (Sone)FDA LinkGeneric 10/2020 - 01/2018
2	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2019 - 04/2012
2	Biological ProductsIBA 11/2018 - 01/2012
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 10/2017 - 01/2016
2	LipidsIBA 10/2017 - 01/2004
2	montelukast (Singulair)FDA Link 10/2017 - 01/2003
2	Bronchodilator Agents (Bronchodilators)IBA 05/2017 - 08/2010
2	ProtollinIBA 01/2017 - 09/2012
2	Oxidants (Oxidizing Agents)IBA 01/2017 - 10/2011
2	EnzymesIBA 01/2017 - 01/2012
2	Chemotactic FactorsIBA 01/2016 - 01/2004
2	Antiviral Agents (Antivirals)IBA 05/2014 - 08/2010
2	Interleukin-22 (IL-22)IBA 11/2013 - 12/2012
2	Oxidoreductases (Dehydrogenase)IBA 07/2013 - 08/2010
2	Histamine (Histamine Dihydrochloride)FDA Link 04/2013 - 04/2012
2	Immunoglobulin E (IgE)IBA 08/2012 - 01/2004
2	ErbB Receptors (EGF Receptor)IBA 04/2012 - 06/2010
2	Proteoglycans (Proteoglycan)IBA 01/2012 - 06/2006
2	GlucocorticoidsIBA 11/2011 - 05/2003
2	p38 Mitogen-Activated Protein KinasesIBA 11/2011 - 04/2010
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 08/2010 - 05/2010
2	Interleukin-33IBA 03/2010 - 10/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2008 - 11/2006
2	InterferonsIBA 02/2008 - 01/2006
2	OligodeoxyribonucleotidesIBA 10/2007 - 05/2002
2	DisintegrinsIBA 04/2007 - 01/2007
2	Metalloproteases (Metalloproteinases)IBA 04/2007 - 01/2007
2	Uridine Triphosphate (UTP)IBA 11/2005 - 12/2002
2	Adenosine Triphosphate (ATP)IBA 11/2005 - 12/2002
1	Azithromycin (Zithromax)FDA LinkGeneric 10/2022
1	Immunoglobulin G (IgG)IBA 01/2022
1	ciclesonide FDA Link 11/2021
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021
1	Leukotriene C4IBA 01/2021
1	Monoclonal AntibodiesIBA 10/2020
1	mepolizumabIBA 10/2020
1	reslizumabIBA 10/2020
1	Dinoprostone (PGE2)FDA Link 10/2019
1	Hydroxyl RadicalIBA 01/2019
1	sulforaphaneIBA 01/2019
1	Nucleic AcidsIBA 01/2019
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	benralizumabIBA 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2018
1	Interleukin-10 (Interleukin 10)IBA 01/2018
1	Thymic Stromal LymphopoietinIBA 10/2017
1	Interferon Type IIBA 04/2017
1	Fluticasone-Salmeterol Drug Combination (Advair)FDA Link 01/2017
1	Salmeterol Xinafoate (Serevent)FDA Link 01/2017
1	Semaphorins (Semaphorin)IBA 01/2017

Therapy/Procedure

8	Therapeutics 11/2018 - 06/2010
1	Bronchial Thermoplasty 01/2019